Summary
Diphenhydramine is a H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.

Brand Name
- Acetadryl
- Advil PM
- Aleve PM
- Allegra Cooling Relief Anti-itch
- Banophen
- Benadryl
- Benadryl Itch Stopping
- Benadryl-D Allergy and Sinus
- Calagel
- Damylin With Codeine
- Dimetapp Nighttime Cold & Congestion
- Diphen
- Diphenhist
- Diphenist
- Excedrin PM Triple Action
- Goody’s PM
- Legatrin PM
- Motrin PM
- Nytol
- Nytol Quickgels
- Percogesic Reformulated Jan 2011
- Siladryl
- Simply Sleep
- Sleepinal
- Sominex
- Triaminic Night Time Cold & Cough
- Tylenol PM
- Unisom
- Unisom Sleep
- Vanamine
- Wal-dryl
- Wal-som
- Zzzquil
Drug Class
- Antihistamine
- Histamine H1 Antagonists
Medical Condition (Indication)
- Allergies
- Cold & Allergy
- Insect Bites & Stings
- Insomnia (Off-Label)
- Itching of Eyes, Nose, or Throat (Pruritus)
- Rash (Urticaria)
- Runny Nose (Rhinorrhea)
- Seasonal Allergies
- Sneezing
- Watery Eyes
Positive Drug Report Risk
- EtG/Alcohol
- Opioids
- PCP
Resources
Brahm NC, Yeager LL, Fox MD, Farmer KC, Palmer TA. Commonly prescribed medications and potential false-positive urine drug screens. Am J Health Syst Pharm. 2010;67(16):1344-1350. doi:10.2146/ajhp090477
