Diphenhydramine

Summary

Diphenhydramine is a H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.

Brand Name

  • Acetadryl
  • Advil PM
  • Aleve PM
  • Allegra Cooling Relief Anti-itch
  • Banophen
  • Benadryl
  • Benadryl Itch Stopping
  • Benadryl-D Allergy and Sinus
  • Calagel
  • Damylin With Codeine
  • Dimetapp Nighttime Cold & Congestion
  • Diphen
  • Diphenhist
  • Diphenist
  • Excedrin PM Triple Action
  • Goody’s PM
  • Legatrin PM
  • Motrin PM
  • Nytol
  • Nytol Quickgels
  • Percogesic Reformulated Jan 2011
  • Siladryl
  • Simply Sleep
  • Sleepinal
  • Sominex
  • Triaminic Night Time Cold & Cough
  • Tylenol PM
  • Unisom
  • Unisom Sleep
  • Vanamine
  • Wal-dryl
  • Wal-som
  • Zzzquil

Drug Class

  • Antihistamine
  • Histamine H1 Antagonists

Medical Condition (Indication)

  • Allergies
  • Cold & Allergy
  • Insect Bites & Stings
  • Insomnia (Off-Label)
  • Itching of Eyes, Nose, or Throat (Pruritus)
  • Rash (Urticaria)
  • Runny Nose (Rhinorrhea)
  • Seasonal Allergies
  • Sneezing
  • Watery Eyes

Positive Drug Report Risk

  • EtG/Alcohol
  • Opioids
  • PCP

Resources

Brahm NC, Yeager LL, Fox MD, Farmer KC, Palmer TA. Commonly prescribed medications and potential false-positive urine drug screens. Am J Health Syst Pharm. 2010;67(16):1344-1350. doi:10.2146/ajhp090477

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EST. 2022